Impact of Keap1/Nrf2 Signaling on Thyroid Physiology and Disease
Dr. Gerasimos Sykiotis from the University of Lausane, Switzerland, will present his most recent findings on "'Impact of Keap1/Nrf2 signaling on thyroid physiology and disease" in a session dedictaed to the "Nrf2 Signaling Pathway".
The synthesis of thyroid hormones depends on the intake of micronutrients including iodine and selenium, and it entails the active production of reactive oxygen species (ROS) in thyroid follicular cells to oxidize iodine and iodinate thyroglobulin, the thyroid hormone precursor. At the same time, like all other tissues, the thyroid gland must also defend itself against oxidative stress, for which it relies on antioxidant defense systems to maintain its own homeostasis in the face of continuous self-exposure to ROS. Over the last few years, Dr. Sykiotis' group has identified multiple links between the Keap1/Nrf2 antioxidant response pathway and thyroid physiology, as well as various thyroid pathologies, including autoimmunity, goiter, hypothyroidism, hyperthyroidism, and cancer.
Dr. Sykiotis' presentation will summarize the main results of these studies and will highlight future perspectives, with a focus on translational implications:
(i) for the pathogenesis and treatment of thyroid diseases;
(ii) for basic research studies using animals with genetically or pharmacologically modified Nrf2 activity; and
(iii) for the use of Nrf2-modulating compounds in clinical studies.
Remember that you can also present your latest research related to this session, by submitting your abstract.
24th Annual ISANH Meeting
Paris Redox 2022 Congress
June 22-24, 2022 - Paris, France
www.isanh.net
