It is an honor to announce the award discerned by ISANH to Dr Pedro Buc Calderon, Université Catholique de Louvain, Belgium for his scientific contribution during ISANH Antioxidants World Congress 2014.
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Dr Buc Calderon is interested about Oxidative Stress Subtle Balance, KEAP1-NRF2 Activation & HSP90 Overexpression: Between Defenses & Adaptation.
According Dr Buc Calderon: "Interestingly, cancer cells are characterized by an increased production of reactive oxygen species (ROS) and rather low levels of antioxidant enzymes. These characteristics represent an advantage in terms of proliferation, but at the same time, they render cancer cells particularly sensitive to an oxidant insult. Modifying the intracellular redox status of cancer cells by targeting the antioxidant enzymes could be an interesting approach. It has been proposed that the Keap1-Nrf2 signaling pathway is hijacking by cancer cells which enhance their resistance against therapeutic drugs by activation of proteins having detoxification and antioxidant abilities. In this context of acquired resistance, an additional mechanism to ensure the survival of cancer cells is the overexpression of the protein chaperone Hsp90."
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