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At your Diary: The 14th ISANH Conference on Oxidative Stress, Redox Homeostasis & Antioxidants will be held in Paris next June 12-13, 2014

ISANHIt is a great pleasure to announce you the organization of 14th International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants, which will be held in Paris, next June 12-13, 2014.



Among questions which will be discussed during Antioxidants 2014 World Congress:

  • How to reduce Oxidative Stress and increase pro-antioxidant states?
  • How to use ROS to reduce oxidatvie stress at the level of mitochondria?
  • What is the exact role of mitochondria to modulate:
    • Nrf2 / Keap 1 pathways?
    • NfKb pathways?

 

Program, Speakers, Registration and Practical Information are available on www.isanh.fr.

Looking forward welcoming you in Paris next June.

ISANH Team

ISANH Anniversary: We need to talk about Redox Signaling Pathway modulation, restoring, reseting more than supplementation with antioxidants: A huge Success

4328The 15th Anniversary of the International Society of Antioxidants (ISANH) organized in Paris  last July 3-4 was a huge success. During ISANH Congress on Antioxidants, one of the main discussion showed that antioxidants play their role by modulating redox signaling pathways and not a counter "balance" to oxidant formation. They act to modulate cells signaling domains in which redox signaling occurs. 
Mitochondria are a localized signlaing domain and ROS (Superoxide and Hydrogen Peroxide) generated by respiratory chain are signaling molecules.

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ISANH Scientific Award 2013 for Pr Katsuhiko Mikoshiba, Pioneer in Neurodegenerative diseases

awardmikoshiba It is an honor to announce the award discerned by ISANH to Pr Katsuhiko Mikoshiba, M.D. Ph.D. Lab. for Developmental Neurobiology RIKEN Brain Science Institute, Saitama, Japan for all his scientific contributions in Neurodegenerative diseases researches.

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The abstracts Book of ISANH 15th Anniversary is now available

Couv

 

The abstracts book of ISANH anniversary includes each abstracts of speakers with oral presentations, but also abstracts accepted for posters presentations.

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Prof Fathi Moussa, from University Paris-Sud, Orsay, France, one of the pioneers in the field of in vivo studies of fullerenes, will present the state of the art on fullerene as powerful antioxidants in 2013: lessons, limits and perspective

moussaDue to its 30 carbon double-bonds C60, the most abundant fullerene, is probably the most efficient free radical scavenger among all known chemical compounds. According to the literature, the range of possible actions of C60 and derivatives as free radical scavengers is impressive, notably in the fields of neurodegenerative disorders and ageing. However, although numerous experiments showed that C60 can efficiently scavenge a large variety of free radicals in vitro, the exact mechanism of its antioxidant action has never been demonstrated in vivo. Possible mechanisms of action remain to be investigated.

 

For more information: www.isanh.fr

Targeting mitochondrial mitohormesis mechanisms: improving cellular antioxidant capacities

GenyAs it will be highlighted by Dr Bernard gény during next ISANH congress, mitochondrial hormesis or mitohormesis can be defined as increased mitochondrial biogenesis, triggered by low doses of mitochondrial ROS generation.

 


Such defense mechanism participates in life span extension but a same amount of ROS might be protective or deleterious, depending on target tissue characteristics. Increasing cellular anti-oxidant defence might nevertheless be a promising therapeutic approach.

 



 

For more information: www.isanh.fr

 



 

 

 

ROS Production in Phagocytes: Why, When and Where?

Nusse

Pr Oliver Nüsse, from University Paris-Sud, Orsay, France will present a strategic topic about ROS production in phagocytes during next ISANH Congress.

Phagocytes produce ROS to kill pathogens. How much radicals and which species are required for efficient killing is still under debate. How does the phagocyte “know” when to stop ROS production? What are the consequences of ROS escaping from the phagosome? To answer these questions, more accurate methods to detect ROS in time and space will be required. Future detection methods need to deal with the diversity of biologically relevant ROS, a wide range of concentration and with localized, short term production.

Among the last publications of Pr Nüsse:

ROS Production in Phagocytes: Why, When and Where?

Abstract

In the phagocytosis field, ROS production by the phagocyte NOX has been associated with pathogen killing for the last 50 years. Since the discovery of nonphagocyte NOX, numerous other roles for ROS production have been identified. Oxidative stress and ROS-mediated signaling have received much attention in recent years. Much lower concentrations of ROS may be required for signaling compared with microbial killing. Based on the discoveries in nonphagocytic cells, it became logical to look for ROS functions distinct from pathogen killing, even in phagocytes. ROS are now linked to various forms of cell death, to chemotaxis, and to numerous modifications of cellular processes, including the NOX itself. ROS functions are clearly concentration-dependent over a wide range of concentrations. How much is required for which function? Which species are required for how much time? Is ROS signaling only a side effect of bactericidal ROS production? One major obstacle to answer these questions is the difficulty of reliable quantitative ROS detection. Signal transduction often takes place on a subcellular scale over periods of seconds or minutes, so the detection methods need to provide appropriate time and space resolution. We present examples of local ROS production, decreased degradation, signaling events, and potentially ROS-sensitive functions. We attempt to illustrate the current limitations for quantitative spatiotemporal ROS detection and point out directions for ongoing development. Probes for localized ROS detection and for combined detection of ROS, together with protein localization or other cellular parameters, are constantly improved.

More information: www.isanh.fr

 

Endothelial Dysfunctions on Intensive Care Units: Targeting Oxidative Stress & Interleukine-10 Modulation

vaisseausanguinDr Laurent Dupic, from Paris Hopitel Necker Hospital will give a translational talk  focusing on oxidative mechanism and opening on therapeutic perspective.

More information: www.isanh.fr

How New Concepts in Redox Biology Changes Strategies for the Development of Antioxidants, by Pr Victor Darley-Usmar

VictorDarleyUsmarOn behalf of Scientific Committee of 12th ISANH Antioxidants World Congress 2013, we are pleased to welcoming Pr Victor Darley-Usmar. Pr Darley-Usmar will give a talk on How New Concepts in Redox Biology Changes Strategies for the Development of Antioxidants.

The impact of this talk that it will argue that since redox signaling is controlled by cellular domains targeting plasma antioxidant status is not a useful strategy.

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Oxidative Stress & Kidney Diseases: From Mechanistic of Oxidative Stress to Therapeutic Approaches

attafDr David Attaf, Paris, France, will highlight the impact of oxidative stress and inflammation on kidney diseases.

The mechanistic of oxidative stress on cellular signaling pathways and gene expression will be underline in term of therapeutics.

Clinical studies will be presented during ISANH Congress.

More information www.isanh.fr

 

ROS as a strategic pharmacological target: The good VS bad side

Rama2Dr Ramaroson Andriantsitohaina, from University of Angers, France will participate to the strategic discussion about the Red Line between Pathologic ROS vs Physiologic ROS:



What kind of strategy we need urgently to determine the basal level of ROS in healthy human which can be used to identify pathologic ROS in unhealthey subject and ultimately guide antioxidants treatment?

 

For more information: www.isanh.fr

 



Redox Proteomics: The next step to oxidative stress revolution

RedoxProteomics

Pr Lars Leichert, from Germany will show the perspective of redox proteomics to detect, diagnose and treat many diseases.


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Dr Lubomira Tothova will talk about Salivary Markers of Oxidative Stress & Antioxidants Status

thotova

The Session 2 of the conference will be dedicated to Non-Invasive Devices to Evaluate Oxidative Stress and Antioxidants

One of the topic of this session is to discuss about Salivary Markers of Oxidative Stress & Antioxidants Status.

This talk will be highlighted by Dr Tothova, from Comenius University, Bratislava, Slovakia.

 

More information: www.isanh.fr

Electrochemical biosensors for the determination of the antioxidants capacities in food and beverages: Potential applications and perspectives

sensor

During the 12th International Conference on Oxidative Stress & Antioxidants 2013, Dr Carole Calas-Blanchard from Université de Perpignan Via Domitia, France will highlight the importance of Electrochemical biosensors for the determination of the antioxidants capacities in food and beverages: Potential applications and perspectives

The determination of antioxidants has been widely investigated in the food-processing industry. Electrochemical biosensors are presented as innovative and promising tools, starting to replace traditional techniques such as spectrophotometry, fluorescence, and gas or liquid chromatography. Their advantages in terms of simplicity, rapidity and low cost respect to conventional techniques promote their investigation and exploitation.

To know more about Biosensors, come and join all attendees of Oxidative Stress & Antioxidants 2013.

More information: www.isanh.fr

Pr Pedro Buc Calderon from Université Catholique de Louvain, Belgium will talk about Exploiting cancer cell redox status to optimize cancer therapy during the ISANH 15th Anniversary

BucCalderon

Pr Pedro Buc Calderon, from Toxicology and Cancer Biology Research Group (GTOX), Louvain Drug Research Institute, Université catholique de Louvain (UCL), Bruxelles, Belgium will highlight how to exploite cancer cell redox status to optimize cancer therapy.


This topic will be held on July 3, during the first day of the 12th International Conference on Oxidative Stress and Antioxidants.


According Pr Buc Calderon Research:

Cancer cells are particularly vulnerable to treatments impairing redox homeostasis. Reactive oxygen species (ROS) can indeed play an important role in the initiation and progression of cancer, and advanced stage tumors frequently exhibit high basal levels of ROS that stimulate cell proliferation and promote genetic instability. In addition, an inverse correlation between histological grade and antioxidant enzyme activities is frequently observed in human tumors, further supporting the existence of a redox dysregulation in cancer cells. This biochemical property can be exploited by using redox-modulating compounds, which represent an interesting approach to induce cancer cell death. Thus, we have developed a new strategy based on the use of pharmacologic concentrations of ascorbate and redox-active quinones.


To know more about Pr Buc Calderon's strategy, you can join attendees of the conference by register here.


More information: www.isanh.fr


Paris Antioxidants 2013 will highlight The Red Line between Pathologic ROS vs Physiologic ROS

ROSDuring Paris Antioxidants 2013, the Scientific Committee will discuss about the kind of strategies we need urgently to determine the basal level of ROS in healthy human which can be used to identify pathologic ROS in unhealthey subject and ultimately guide antioxidants treatment?

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Oxidative Stress & Antioxidants Biomarkers: Moving towards a Successful Standard

ISANHbrunDuring Paris Antioxidants 2013, our aim is to highlight the controversies of antioxidants activities and oxidative stress markers evaluation methods. In fact, the analysis of these markers can be realized by many different methods. But are these methods equivalent ? Which one is the best, the most representative? How to simply compare results coming from different methods?

The last statements of European Food Safety Authority (EFSA) which gave negative opinions about a lot of antioxidants and the lack of reliability for their dosing methods, report the frailty of clinical studies in antioxidants field. Besides, in scientific literature, a gap is reported between in-vitro results and clinical evidences.

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Oxidative Stress & Antioxidants Exhibition: Commercial Kits, cells and products for in vitro / in vivo oxidative stress and antioxidants tests

kitschemistryParis Antioxidants 2013 will gather all actors of the world of oxidative stress and antioxidants: Kits, ingredients, cells, products, devices...

If you wish to present your ORIGINAL innovations, please don't hesitate to submit your abstract for oral or poster presentations.

You can also exhibit your innovations in the special "exbition space".

For more information, please contact us.

Antioxidants Challenges 2013: The non-invasive devices

devicesSaliva will be a perfect target to evaluate oxidative stress and antioxidants.

During Paris Antioxidants 2013, the scientific committee will invite all scientifics, start up and industrials to present their innovations and devices to evaluate  oxidative stress and antioxidants level in humans.

If you are interested to present your innovative non-invasive devices, please don't hesitate to contact us.

Pr John W. Finley, pionner in Standardisation Measurment Methods, will chair the 15th Anniversary of ISANH congress

JohnFinley

Pr Finley's research interests include development of new low calorie lipids and carbohydrates and their biological effects, natural antioxidants and ingredients that reduce cardiovascular inflammation. 

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