Cancer cells display an overproduction of reactive oxygen species resulting from an exaggerated intrinsic oxidative stress. However, the concept of deleterious oxidants versus beneficial antioxidants has recently evolved. Indeed, molecules like natural coumarins have shown anti-oxidant or pro-oxidant properties depending on their intracellular concentration. Therefore, the team has investigated the structure-activity relationship of a variety of coumarin derivatives in terms of cytotoxicity towards human and murine carcinoma cell lines (HT29, HepG2, A549, MCF7, OVCAR and CT26).
During ISANH Antioxidants World Congress 2014, which will be held in Paris on June 12-13, Pr Frédéric Batteux, from University Paris Descartes, France will highlight the strategies and perspectives of Chalcone-Coumarin Derivatives as Potential Anti-Cancer Drugs.
If you are interested to know more about this strategic topic, come and join Antioxidants World Congress.
For more information: www.isanh.fr
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