Prof Fathi Moussa, from University Paris-Sud, Orsay, France, one of the pioneers in the field of in vivo studies of fullerenes, will present the state of the art on fullerene as powerful antioxidants in 2013: lessons, limits and perspective

moussaDue to its 30 carbon double-bonds C60, the most abundant fullerene, is probably the most efficient free radical scavenger among all known chemical compounds. According to the literature, the range of possible actions of C60 and derivatives as free radical scavengers is impressive, notably in the fields of neurodegenerative disorders and ageing. However, although numerous experiments showed that C60 can efficiently scavenge a large variety of free radicals in vitro, the exact mechanism of its antioxidant action has never been demonstrated in vivo. Possible mechanisms of action remain to be investigated.

 

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