During Paris Redox 2015, Pr Thornalley from the University of Warwick, UK, talked about the Screening for antioxidant activators of Nrf2 - Have we been misreading the signals?
Pr Thornalley, from the University of Warwick, Coventry UK, discussed about "Screening for antioxidant activators of Nrf2 - Have we been misreading the signals? Frequency modulated translocational oscillations of Nrf2 regulate the Antioxidant Response Element cytoprotective transcriptional response" during the first day of the 15th International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants, held on June 22-24 in Pasteur Institute, Paris
Nrf2 oscillation and not Nrf2 accumulation?
The discovery that Nrf2 undergoes translocational oscillations from cytoplasm to nucleus in human cells with frequency modulation linked to activation of a stress-stimulated cytoprotective response raises the prospect that the Nrf2 works mechanistically analogous to a wireless sensor. Herein I consider how this new model of Nrf2 oscillation resolves previous inexplicable experimental findings on Nrf2 regulation and why it is fit-for-purpose. Further investigation is required to assess how generally applicable the oscillatory mechanism is and if characteristics of this regulatory control can be found in vivo. The model identifies multiple re-enforcing receptors for Nrf2 activation, suggesting that potent Nrf2 activation for improved health and treatment of disease may be achieved through combination of Nrf2 system stimulants.
ISANH team
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