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This is archive site for 17th International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants which was held at Institut Pasteur in Paris, France from June 13 to 15, 2016. Please click here to back main site.

 

 

Physiological glycation by methylglyoxal and prevention by glyoxalase 1 will be presented by Pr. Thornalley

Thornalleynew

Professor Paul J. Thornalley from the University of Warwick, the United Kingdom, will give a talk about Physiological glycation by methylglyoxal and prevention by glyoxalase 1 - involvement in disease mechanisms and development of glyoxalase 1 inducer therapeutics, at the Paris Redox World Congress 2016.


According to Pr. Thornalley, methylglyoxal (MG) is a dicarbonyl metabolite and precursor of major quantitative advanced glycation endproducts (AGEs) of protein and DNA, hydroimidazolone MG-H1 and imidazopurinone MGdG, respectively. Glyoxalase 1 (Glo1) of the cytoplasmic glyoxalase pathway provides the major route for metabolism of MG and enzymatic deference against MG glycation. Accumulation of MG - “dicarbonyl stress” - occurs in ageing and metabolic and vascular disease. Dicarbonyl stress is a driver for insulin resistance and inflammation of obesity, vascular complications in diabetes and renal failure, and cardiovascular disease. Small molecule inducers of Glo1 expression are in clinical evaluation for therapeutic agents to counter dicarbonyl stress-linked disorders.

 

Last news

  1. Pr Pagano will present his work about the challenges and perspectives of Nox Inhibitors during Paris Redox 2016

  2. Are Reactive Oxygen Species Actually Reactive Sulfide Species?: A strategic question which will be answered by Pr Olson

  3. Pr. Siegfried Hekimi from McGill University will give the keynote lecture during Paris Redox 2016 and will talk about Mitochondrial dysfunction and longevity

  4. Pr Harald Schmidt will give a talk about Reactive oxygen-related diseases: therapeutic targets and emerging clinical indications

  5. Physiological glycation by methylglyoxal and prevention by glyoxalase 1 will be presented by Pr. Thornalley

  6. Marvin Edeas alerted about antioxidant anti-diabetic agents on tumor metastasis

  7. Pr. Nüsse will give a presentation about the complexity of ROS detection in harsh environments

  8. NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis: Antioxidants Again Linked to Cancer’s Spread

  9. Pre-clinical evidences that antioxidant supplementation corrects sperm DNA oxidative damage and improves reproductive success

  10. Pr. Ulla Knaus from the University College Dublin will give a talk about ROS deficiency as disease risk

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