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This is archive site for 17th International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants which was held at Institut Pasteur in Paris, France from June 13 to 15, 2016. Please click here to back main site.

 

 

Physiological glycation by methylglyoxal and prevention by glyoxalase 1 will be presented by Pr. Thornalley

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Professor Paul J. Thornalley from the University of Warwick, the United Kingdom, will give a talk about Physiological glycation by methylglyoxal and prevention by glyoxalase 1 - involvement in disease mechanisms and development of glyoxalase 1 inducer therapeutics, at the Paris Redox World Congress 2016.


According to Pr. Thornalley, methylglyoxal (MG) is a dicarbonyl metabolite and precursor of major quantitative advanced glycation endproducts (AGEs) of protein and DNA, hydroimidazolone MG-H1 and imidazopurinone MGdG, respectively. Glyoxalase 1 (Glo1) of the cytoplasmic glyoxalase pathway provides the major route for metabolism of MG and enzymatic deference against MG glycation. Accumulation of MG - “dicarbonyl stress” - occurs in ageing and metabolic and vascular disease. Dicarbonyl stress is a driver for insulin resistance and inflammation of obesity, vascular complications in diabetes and renal failure, and cardiovascular disease. Small molecule inducers of Glo1 expression are in clinical evaluation for therapeutic agents to counter dicarbonyl stress-linked disorders.

 

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  4. Pr Thierry Patrice will talk about the secondary ROS production in patients with cell lung cancers

  5. Pr. Siegfried Hekimi from McGill University will give the keynote lecture during Paris Redox 2016 and will talk about Mitochondrial dysfunction and longevity

  6. Pr. Pedro Buc Calderon will give a presentation about how NQO1 overexpression modulates breast cancer cell sensitivity to quinone-based chemotherapeutic agents

  7. Mitochondria and oxidative stress in age-related muscle loss

  8. Acute, chronic lung diseases and oxidative stress : targeting respiratory infections, COPD and viral-induced exacerbations of COPD

  9. Cutaneous free radical induction by sunlight in different spectral regions and counteraction by systemically or topical applied antioxidants, will be presented by Pr. Meinke

  10. NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis: Antioxidants Again Linked to Cancer’s Spread

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