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Antioxidant systems in brain astrocytes: sources of cysteine for glutathione

1408 McBean G 004 croppedDr Gethin McBean from University College Dublin, Ireland, will give a presentation about antioxidant systems in brain astrocytes: sources of cysteine for glutathione at the 17th International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants, which will be held at Institut Pasteur in Paris, from June 13 to 15, 2016.

According to Dr McBean astrocytes supply neurons with the antioxidant, glutathione. Cysteine is the precursor of glutathione and is imported as cystine via the plasma-membrane cystine glutamate exchanger.  Recent evidence has shown that the transsulphuration pathway that converts methionine to cysteine also contributes to glutathione in astrocytes. Data on the relationship between the cystine glutamate exchanger and the transsulphuration pathway and changes in response to oxidative stress in astrocytes will be presented. The implications of this work for targeting pathways of cysteine metabolism in neurodegenerative disease will be discussed.

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