Pr Huang will talk about Redox-Sensitive GFP and YFP Sensors for Monitoring Nuclear Redox Dynamics during Antioxidants World Congress 2015

Pr Huang, Research Director of CNRS, will describe during the ISANH Antioxidants World Congress 2015, the use of genetically encoded biosensors as a novel method to investigate intracellular redox species dynamics in response to stress.

 "Dynamic changes of intracellular reactive oxygen species (ROS) levels and associated redox regulation contribute to cell fate decisions, such as proliferation, differentiation, and apoptosis. It is recognized that the spatio-temporal pattern of intracellular ROS and redox changes is highly non-uniform between and within cellular compartments.

Likewise, individual redox systems have distinct functions and are subject to independent regulation. Despite considerable interest and effort, technical limitations in measuring intracellular defined oxidant species and defined redox processes have hindered the progress of redox biology. Genetically encoded biosensors provide an alternative way to overcome these limitations." The talk will describe the use of redox-sensitive green fluorescent protein (GFP) and yellow fluorescent protein (YFP)-based sensors for investigating nuclear redox dynamics in response to various stress factors.

To know more about ISANH Antioxidants World Congress 2015 that will be held on 22-24 June in Paris and the preliminary agenda, please visit www.isanh.net