The Impact of Oxidative DNA Damage and Stress on Telomere Homeostasis
Prof. Patricia L. Opresko from University of Pittsburgh Graduate School of Public Health & UPMC Hillman Cancer Center, USA will join the Paris Redox 2021 congress and give a presentation entitled "The Impact of Oxidative DNA Damage and Stress on Telomere Homeostasis".
The study describes telomeres as protective nucleoprotein-DNA caps at chromosome ends that profoundly influence genome stability and human health. Telomeric DNA is highly susceptible to damage caused by oxidative stress and inflammation. In series of complementary biochemical and cellular experiments, we discovered that oxidative damage to the nucleotide pools and to duplex telomeric DNA impair telomere maintenance. We demonstrate that targeting 8-oxoguanine damage to just the telomeres is sufficient to induce hallmarks of telomere dysfunction, driving genome instability in human cancer cells and cellular senescence in non-diseased cells.
Paris Redox 2021 Congress
October 13-15, 2021 - Paris, France & Online
www.isanh.net
