Hallmarks of Aging: An Expanding Universe
Aging is driven by hallmarks fulfilling the following three premises: (1) their age-associated manifestation, (2) the acceleration of aging by experimentally accentuating them, and (3) the opportunity to decelerate, stop, or reverse aging by therapeutic interventions on them.
In their review published in Cell Press Journal, Prof. Guido Kroemer, keynote speaker at Redox Medicine 2023 and member of RMS scientific committee, and his colleagues proposed the following twelve hallmarks of aging: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis.
These hallmarks are interconnected among each other, as well as to the recently proposed hallmarks of health, which include organizational features of spatial compartmentalization, maintenance of homeostasis, and adequate responses to stress.
In case you missed Prof. Kroemer's talk on "Hallmarks of Aging & Redox Medicine: An Expanding Universe" during Redox Medicine 2023, conference recordings are available.
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Redox Medicine 2023 Congress
June 21-23, 2023 - Paris, France
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