Redox and Progeria: Advances and Perspective
Dr. Ricardo Villa-Bellosta from University of Santiago de Compostela, Spain will give a major talk entitled "Redox and Progeria: Advances and Perspective".
Dr. Ricardo Villa-Bellosta will talk about the cellular balance between oxidation and reduction reactions (redox state). Hence, this balance plays a critical role in aging. Thus, both increases in mitochondrial ROS and a deterioration in antioxidant status stimulate aging. Consistently, a mouse model of premature aging showed an increased level of mitochondrial reactive oxygen species (ROS), and a reduced basal antioxidant capacity, including loss of the NADPH-coupled glutathione redox system.
Genes associated with cytoprotective defense systems, including those encoding proteins involved in glutathione (GSH) production and GSH/NADPH regeneration, are regulated by nuclear factor erythroid 2-related factor 2 (NRF2), indicating that NRF2 regulates the redox state. Thus, loss of NRF2 function is key piece to many pathologic conditions, including progeria, aging and age-related diseases.
Although various strategies have been employed to prolong the lifespan of animals, the most effective thus far are those that augment the reducing power of cells, specifically the supply of GSH and NADPH. These pools are directly involved in the maintenance of the glutathione redox system and can be considered markers of redox status.
Paris Redox 2021 Congress
October 13-15, 2021 - Paris, France & Online
www.isanh.net
