Advances in Redox Medicine: Selected Short Oral Presentations 2024
The field of redox medicine focuses on the role of oxidative stress and redox signaling in health and disease. Recent research has provided new insights into the mechanisms and potential therapeutic applications of redox-active compounds. The recent collection of oral presentations provides a comprehensive overview of the latest advancements in Redox Medicine.
1. Therapeutic Efficacy of Novel Conjugates Based On Gold and Cerium Oxide Nanoparticles in Rats with Metabolic Dysfunction-Associated Steatohepatitis
Gregori Casals, Hospital Clinic Barcelona-IDIPAPS, Spain
This study investigates the therapeutic potential of novel conjugates based on gold and cerium oxide nanoparticles in treating metabolic dysfunction-associated steatohepatitis in rats. It introduces an innovative approach using nanotechnology for the treatment of liver diseases associated with metabolic dysfunction, showcasing significant potential for clinical translation.
2. Endothelial Cell Redox Modulation through a Synthetic Thiol Compound Tuning the Metabolic Profiles and Stress Responses in Hypoxia and Normoxia
Michela Bruschi, University of Urbino Carlo Bo, Italy
This research explores the effects of a synthetic thiol compound on endothelial cell redox modulation, metabolic profiles, and stress responses under hypoxic and normoxic conditions. It highlights the potential of synthetic compounds to modulate cellular redox states and metabolic responses, offering new therapeutic avenues for diseases related to endothelial dysfunction.
3. About Oxidative Stress, Placenta, Zika Virus and Therapeutic Potential of Natural Products
Marília Oliveira Goulart, Federal University of Alagoas, Brazil
This presentation investigates the interplay between oxidative stress, the placenta, and Zika virus infection, and evaluates the therapeutic potential of natural products. It provides novel insights into the role of oxidative stress in Zika virus pathogenesis and highlights natural products as potential therapeutic agents.
4. Structure-Based Drug Design for Targeting Thioredoxin Reductase-Like Enzymes: Paving the Way to Treat Parasitic Infections and Other Diseases
Matteo Ardini, University of L'Aquila, Italy
This study focuses on the structure-based design of drugs targeting thioredoxin reductase-like enzymes to treat parasitic infections and other diseases. It demonstrates an innovative approach to drug design, targeting a critical enzyme involved in redox balance and offering new treatments for parasitic and other diseases.
5. Thiosulfate Sulfurtransferase (TST) Deficiency Improves the Metabolic Benefits of Calorie Restriction in Male Mice
Shaden Melhem, University of Edinburgh, United Kingdom
This research investigates the impact of TST deficiency on the metabolic benefits of calorie restriction in male mice. It provides insights into the metabolic pathways influenced by TST, suggesting potential targets for enhancing the benefits of calorie restriction.
6. The Duality of Reactive Sulfur Species: Cellular Oxidants and Antioxidants
Christopher Switzer, University of Leicester, United Kingdom
This study explores the dual role of reactive sulfur species as both cellular oxidants and antioxidants. It enhances understanding of the complex role of sulfur species in cellular redox balance, contributing to the development of novel redox-based therapies.
7. Preferential Production of PGF2α in SARS-Cov-2 Permissive Human Lung Epithelial Cells
Rosangela Silva Santos, University of Sao Paulo, Brazil
8. HO-1 Regulation in BACH1 Knockout Mice Following Sepsis
Raghavan Pillai Raju, Medical College of Georgia, USA
This research examines the regulation of HO-1 in BACH1 knockout mice following sepsis. It provides new insights into the regulatory mechanisms of HO-1 in response to sepsis, potentially informing new therapeutic strategies.
9. Mangifera indica L. Extracts: A Source of Bioactive Compounds to Target Redox Balance Circuits in Cancer and Obesity Models
Antonella D'Anneo, University of Palermo, Italy
This study investigates the potential of Mangifera indica L. extracts to target redox balance circuits in cancer and obesity models. It highlights the therapeutic potential of natural extracts in modulating redox balance, offering new strategies for managing cancer and obesity.
