Peroxiredoxin Promotes Longevity and H2O2-Resistance in Yeast through Redox-Modulation of Protein Kinase A
Prof. Mikael Molin, associate professor at the Division of Systems Biology, Chalmers University of Technology, Sweden will join the Paris Redox 2021 Congress which will be held on October 13-15, 2021 and will present a talk entitled "Peroxiredoxin Promotes Longevity and H2O2-Resistance in Yeast through Redox-Modulation of Protein Kinase A".
Through his researches, Prof. Molin confirms that peroxiredoxins are antioxidants, chaperones and modulators of signaling that have emerged as conserved regulators of aging and age-related diseases e.g. cancer.
He adds that their multitude of functions have lead to questions by which mechanism(s) they execute their longevity-promoting effects. He has shown that the most highly expressed 2-cysteine peroxiredoxin, Tsa1, is a powerful regulator of both yeast replicative aging and age-related proteostasis as well as of the nutrient signaling hub protein kinase A (PKA).
During his presentation, he will demonstrate the roles of Tsa1 in slowing down aging and in protecting cells from hydrogen peroxide stress are not linked to H2O2-scavenging but instead may be entirely attributed to a function of Tsa1 in hydrogen peroxide signaling targeting the catalytic subunits of PKA in a unique and second-messenger (cyclic AMP)-independent manner.
Paris Redox 2021 Congress
October 13-15, 2021 - Paris, France & Online
www.isanh.net
