Skeletal Muscle Redox Signaling in Rheumatoid Arthritis
Dr. Johanna T. Lanner, Associate Professor from Karolinska Institute, Sweden, will present her recent study on Skeletal Muscle Redox Signaling in Rheumatoid Arthritis.
Dr. Lanner describes Rheumatoid arthritis (RA) as a chronic inflammatory disease characterized by synovitis and the presence of serum autoantibodies. In addition, skeletal muscle weakness is a common comorbidity that contributes to inability to work and reduced quality of life. Loss in muscle mass cannot alone account for the muscle weakness induced by RA, but instead intramuscular dysfunction appears as a critical factor underlying the decreased force generating capacity for patients afflicted by arthritis. Oxidative stress and associated oxidative post-translational modifications have been shown to contribute to RA-induced muscle weakness in animal models of arthritis and patients with RA. However, it is still unclear how and which sources of reactive oxygen and nitrogen species (ROS/RNS) that are involved in the oxidative stress that drives the progression toward decreased muscle function in RA. Nevertheless, mitochondria, NADPH oxidases (NOX), nitric oxide synthases (NOS) and phospholipases (PLA) have all been associated with increased ROS/RNS production in RA-induced muscle weakness. In this review, we aim to cover potential ROS sources and underlying mechanisms of oxidative stress and loss of force production in RA. We also addressed the use of antioxidants and exercise as potential tools to counteract oxidative stress and skeletal muscle weakness.
Read more about the paper here: https://doi.org/10.1042/CS20190728
Paris Redox 2021 Congress
October 13-15, 2021 - Paris, France & Online
www.isanh.net
