Potential Roles of Redox Dysregulation in the Development of Schizophrenia
Prof. Diana O. Perkins from University of North Carolina, USA will join the Paris Redox 2021 Congress and give a presentation entitled "Potential Roles of Redox Dysregulation in the Development of Schizophrenia".
The study explains the converging evidence implicates redox dysregulation as a pathological mechanism driving the emergence of psychosis. Increased oxidative damage and decreased capacity of intracellular redox modulatory systems are consistent findings in persons with schizophrenia as well as in persons at clinical high risk who subsequently developed frank psychosis. Levels of glutathione, a key regulator of cellular redox status, are reduced in the medial prefrontal cortex, striatum, and thalamus in schizophrenia. In humans with schizophrenia and in rodent models recapitulating various features of schizophrenia, redox dysregulation is linked to reductions of parvalbumin containing gamma-aminobutyric acid (GABA) interneurons and volumes of their perineuronal nets, white matter abnormalities, and microglia activation. Importantly, the activity of transcription factors, kinases, and phosphatases regulating diverse aspects of neurodevelopment and synaptic plasticity varies according to cellular redox state.
Paris Redox 2021 Congress
October 13-15, 2021 - Paris, France & Online
www.isanh.net
