Ferrous Iron-Dependent Pharmacology
Prof. Adam R Renslo from University of California, USA will join the Paris Redox 2021 Congress and give a presentation entitled "Ferrous Iron-Dependent Pharmacology".
Prof. Renslo will stress on the points below:
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- Iron cycles between the ferric and ferrous oxidation states to empower enzyme function but also during its uptake, export, and storage, with the ferrous state being generated transiently and in limited concentrations to prevent oxidative damage to the cell.
- Until very recently, it has not been possible to study the ferrous ion specifically, largely due to its much poorer ligation by small molecule or protein siderophores, as compared to the ferric ion.
- The emerging role of ferrous iron in a form of iron-dependent cell death (ferroptosis), and in supporting the proliferation of some of the most aggressive cancers has given new urgency to the study of cellular ferrous iron in biology and disease.
- The clinical success of the antimalarial artemisinin provides inspiration as well as a chemical and conceptual framework for the development of a new class of therapeutic agents exhibiting ferrous iron dependent pharmacology.
Paris Redox 2021 Congress
October 13-15, 2021 - Paris, France & Online
www.isanh.net
